This white paper is written for CIOs and IT executives tasked with providing a strategic vision for delivering high-quality business applications at a reasonable price. It addresses high-level objectives, such as aligning IT with the business, improving IT service quality, and reducing IT costs, and also provides a structure for addressing tactically-oriented challenges, such as superior end-to-end application performance management. The paper discusses end-to-end application performance management in the context of the impact to the business. It then highlights CA's application quality and performance management solutions for both Web and mainframe applications, with particular focus on the integration of CA Wily with AQM Solutions' TRILOGexpert APC for TriTune with Performance Desktop. This combination opens up the "black box" of Web-to-mainframe transactions, providing visibility essential to the process of effectively addressing end-to-end application performance management. It concludes with the Enterprise Management Associates (EMA) perspective on the market in general, and on the CA solution in particular.